摘要：

从构象渐变的观点,对蛋白质热变性现象进行了系统的分析,发现以前用二态模型无法解释的实验数据,可以用渐变的观点做出合理的解释.给出在实验中可以进一步验证热变性过程具有构象渐变特征的预测结果.

关键词： 蛋白质热变性;;二态假说;;构象渐变

Abstract: From the viewpoint of sequential model,thermal denaturation process is analyzed systematically.It is found that the experimental data can not be explained in terms of two?state model previously,but can be explained by sequential model now.The predicted results of further experiment that is about a thermal denaturation process has the feature of the sequential process of conformation is given in this paper.?

Keywords: thermal denaturation; two-state model; conformational sequential process

收稿日期:

基金项目: 国家自然科学基金资助项目(39960023)